Imperceptible adversarial attacks aim to fool DNNs by adding imperceptible perturbation to the input data. Previous methods typically improve the imperceptibility of attacks by integrating common attack paradigms with specifically designed perception-based losses or the capabilities of generative models. In this paper, we propose Adversarial Attacks in Diffusion (AdvAD), a novel modeling framework distinct from existing attack paradigms. At each step, much subtler yet effective adversarial guidance is crafted using only the attacked model without any additional network, which gradually leads the end of diffusion process from the original image to a desired imperceptible adversarial example. Grounded in a solid theoretical foundation of the proposed non-parametric diffusion process, AdvAD achieves high attack efficacy and imperceptibility with intrinsically lower overall perturbation strength.